Experts from both Estonia and Finland are studying electrospinning methods in polymeric wound-care. For the recently published study, the researchers utilized combining bi-layered carriers from a mixture of sodium alginate (SA) and polyvinyl alcohol (PVA).
The carriers were made by solvent casting and then each 3D printing and electrospinning. Moreover, they were identified and experimented concerning the protection and performance of cells. This is along with adhesive and physical attributes.
Since they are eventually meant to heal, wound dressings are also supposed to avoid infection by bacteria. These days, the carriers are made via both artificial and natural polymers and are intended to offer
- Long-term functionality
- Tissue recovery
- Prevention of further damage
- A moist healing setting
- Insignificant bother to the patient
“Mechanical and adhesive properties of wound dressings determine their producibility and durability upon storage and usage,” said the researchers. “In addition, bioactive wound dressings with biologically active ingredients and/or active pharmaceutical ingredients (APIs), such as antibiotics, anti-inflammatory agents, vitamins and growth factors, are continuously being developed.”
Here bruise dressings are made by additive manufacturing, solvent fitting, and electrospinning. This is a technique providing structurally more strong films.
Electrospinning is environmentally important and becoming frequently widespread among experts. Additive manufacturing, particularly with bioprinting, is utilized for:
- Customization of medical devices
- Drug delivery systems
- Tissue engineering
“The aim of this study was to investigate a combinational technique for the fabrication of bi-layered carriers for the API delivery,” said the researchers.
“The designed systems with modified surface layers were based on a polymer blend of PVA and SA. An electrospun layer was added onto the surface of solvent cast films of the same composition. The physicochemical, mechanical, adhesive properties of the carriers were characterized and compared with similar bi-layered carriers with 3D printed macroporous surface layer.”
Electrospinning was sluggish, with a low degree of blending fibers. The experts reported ‘no noticeable changes’ in the fibers after crosslinking both.