A researcher at the University of Waterloo is combining additive manufacturing and his nanomedicine expertise. His aim is to make a novel way to shield women from contracting HIV.
An associate professor in UW’s School of Pharmacy, Emmanuel Ho is creating an intra-vaginal band that would offer accurate precise dosages of medicine that could prevent HIV infection at the location of transmission. Ho said that this will enable women to shield themselves.
The band is created of medical-level plastic with void tubing and miniature openings. Medicines packed into the ring that is put in the vagina is gradually discharged and consumed by the body. The researcher is experimenting with a mix of anti-HIV and anti-inflammatory medicines. Inflammation in the vagina raises the danger of getting HIV. This is as the inflammation draws the immune cells that are infected by the virus.
“If a woman has high levels of inflammation in the genital tract, then the probability of HIV infection is much higher,” explains Ho’s partner Keith Fowke, professor and head of Medical Microbiology and Infectious Diseases at the University of Manitoba.
Discharging anti-inflammation drugs straight could lessen the danger. The anti-HIV drug could battle the virus if a lady is affected. “It’s kind of like a two-pronged approach,” says Ho.
Intra-vaginal bands with a comparable design and shape like NuvaRing have been certified for hormone replacement treatment and birth control.
But Ho mentioned that an additively manufactured print provides a more accurate design and drug distribution. Also, it is affordable and prevents the waste from conventional production where melted polymers are drained into a mold.
The ring by Ho could be utilized for different medicines. This includes hormonal contraceptives. Distributing it to the location would lessen the number of drugs required. This would mean less side effects.
Anti-HIV treatment and condoms are present to avoid HIV infection. However, cultural and social factors may hinder the usage of condom. Another hindrance is the accessibility in growing countries and oral drugs require to be consumed daily.
The band would provide a distinct effective and timely approach. Ho stated that this would be a fresh choice.
The research lately got a donation from the Canadian government to get onto animal experimenting with the Centers for Disease Control andPrevention and the University of Manitoba in the United States. This brings it a step nearer to actuality from the concept.
Internationally, infection rates are on the increase for HIV. HIV is a virus that triggers AIDS and kills one million humans internationally every year. This is as stated by UNAIDS.